X-ray inducible photodynamic therapy

We are developing a novel treatment method called X-ray inducible photodynamic therapy or X-PDT. The technology aims to address the shallow penetration issue of photodynamic therapy, which is otherwise a highly selective and effective treatment modality. The idea is to use a nanoparticle scintillator material as a transducer; under X-ray irradiation, the nanoparticles produce X-ray excited optical luminescence (XEOL) that can activate nearby photosensitizers in situ. Due the excellent tissue penetration of X-ray, X-PDT can be triggered in any part of a body with comparable efficiency.

Relative Publication(s):
Nano Letters, 2015, in Press. (DOI: 10.1021/nl504044p)