Novel MRI contrast agents with high r1/r2 relaxivities

Our research team is working on developing novel contrast agent for magnetic resonance imaging or MRI. One of the recent developments are Gd(III) encapsulated carbon dots or Gd@C-dots. The r1 relaxivity of Gd@C-dots is several times higher than clinically used Gd contrast agents, such as Gd-DTPA. Meanwhile, due to the non-biodegradability of carbon, Gd@C-dots show zero Gd leakage in vivo, minimizing the risk of Gd-associated side effects such as nephrogenic systemic fibrosis. Another example is Fe5C2 nanoparticles. Fe5C2 has a magnetic moment that is almost twice that of iron oxides. With appropriate surface modification, Fe5C2 nanoparticles show an r2 relaxivity that is close to 1000 mM-1s-1 , making them promising T2 contrast agents.

Relative Publications:

Advanced Materials, 2014, 26, 6761–6766.
Theranostics, 2013, 3, 650-657.
Small. 2014;10(7):1245-9.